安非他命誘發大白鼠之行為敏感化受環境轉換效應抑制

Please use this identifier to cite or link to this item: https://dyhuir.dyhu.edu.tw/ir/handle/987654321/297

Title:	安非他命誘發大白鼠之行為敏感化受環境轉換效應抑制
Authors:	王英洲;蔡世仁;蕭世朗
Keywords:	行為敏感化;環境置換效應;水合三氯乙醛;安非他命;Behavioral sensitization;Context switch effect;Chloral hydrate;Amphetamine
Date:	2003/02
Issue Date:	2011-09-02T06:47:44Z
Abstract:	此研究主要是給予大白鼠慢性安非他命注射後，觀察其行為運動量的表現，是否因環境轉換效應而有所影響，並運用麻醉劑的阻隔，進而得到單純的安非他命藥物效果。為了得到一個不受任何環境因素干擾的安非他命作用，大白鼠分別於實驗室或動物房內接受水合三氯乙醛麻醉，接著給予安非他命的注射；結果發現，麻醉劑可以有效的移除環境因素，得到一個無環境干擾的行為敏感化基準，研究結果建議利用此基準值為基礎，進而研究環境轉換效應與行為敏感化的關係；且安非他命用藥環境必須與行為測驗環境相同，否則行為敏感化的表現會因環境轉換而受到抑制。 The purpose of this study was to compare the context switch effects of amphetamine challenge on the locomotor behavior following the chronic amphetamine treatment. The rats either in vivairum or laboratory were anesthetized with chloral hydrate during the amphetamine(AMPH) pretreatment in order to get “pure" amphetamine induced behavioral sensitization without any contextual disturbance. we suggest that “pure”drug effect can be served as the "baseline" to study the behavioral changes related to the contextual association. The effect of behavioral sensitization produced by AMPH challenge after repeated AMPH administrations were inhibited by contextual change.
Relation:	經國學報第十九期:001-010
Appears in Collections:	[Journal of Deh Yu College of Nursing and Health] Journal of Ching Kuo Institute of Management and Health 19

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